Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy.

Over the past two decades, molecular targeted diagnostic and therapeutic agents have dramatically improved cancer diagnosis and treatment. Targeting allows the preferential delivery of therapeutic, diagnostic, or imaging agents to the intended site. Advances in nanotechnology have enabled the development of a variety of targeted nanoparticle platforms for diagnostic and therapeutic applications...

Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury.

Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to p...

Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes

BACKGROUND Magnetic liposomes (MLs) are phospholipid vesicles that encapsulate magnetic and/or paramagnetic nanoparticles. They are applied as contrast agents for magnetic resonance imaging (MRI). MLs have an advantage over free magnetic nanocores, in that various functional groups can be attached to the surface of liposomes for ligand-specific targeting. We have synthesized PEG-coated sterical...

Iron Oxide Nanoparticle-Micelles (ION-Micelles) for Sensitive (Molecular) Magnetic Particle Imaging and Magnetic Resonance Imaging

BACKGROUND Iron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve as a more sensitive and quantitative alternative to MRI. However, MPI requires magnetic particles with specific magnetic properties for optimal...

Superparamagnetic Iron Oxide (SPIO)-enhanced Liver MR Imaging with Ferucarbotran